A Simple Guide to SARMs: Definition, Side Effects and Products


SARMS, short for Selective Androgen Receptor Modulators, are a class of compounds designed to selectively target and stimulate androgen receptors in the body. Unlike traditional steroids that impact various tissues, SARMS focus on specific areas, such as muscle and bone tissues. This selective approach makes them a popular choice among fitness enthusiasts looking for tailored results.

How SARMS Work?

SARMS work by binding to androgen receptors in a tissue-selective manner. This binding initiates cellular changes, promoting muscle growth, fat loss, and improved athletic performance. The specificity of SARMS reduces the risk of unwanted side effects commonly associated with traditional steroids.

  1. RAD140 (Testolone):
    Function: Known for promoting muscle growth and enhancing strength, RAD140 is a potent SARM often chosen by bodybuilders seeking substantial results.
  2. Ligandrol (LGD-4033):
    Function: Ligandrol is recognized for its muscle-building properties and is commonly used during bulking cycles to increase lean muscle mass.
  3. Ostarine (MK-2866):
    Function: Ostarine is versatile, helping with both muscle gain and fat loss. It’s often chosen for cutting cycles to preserve muscle during calorie deficits.
  4. Andarine (S-4):
    Function: Andarine contributes to muscle development and is known for providing a lean and aesthetic appearance.
  5. MK-677: MK-677 is often mentioned in discussions about muscle growth. It is a growth hormone secretagogue that increases levels of growth hormone and insulin-like growth factor 1 (IGF-1).

SARMS Side Effects

While Selective Androgen Receptor Modulators (SARMS) have gained popularity for their targeted effects, it’s essential to be aware of potential side effects associated with their use. Here’s a breakdown of common side effects that users may experience:

  1. Testosterone Suppression:
    Description: SARMS can suppress natural testosterone production. This occurs because the body recognizes the exogenous SARMs as androgens, leading to a temporary decline in the production of natural testosterone.
    Mitigation: Users often incorporate post-cycle therapy (PCT) to help restore testosterone levels after a SARMS cycle.
  2. Mood Swings and Irritability:
    Description: Some individuals may experience mood swings or increased irritability while using SARMS. These changes in mood are attributed to hormonal fluctuations.
    Mitigation: Monitoring dosage and incorporating a balanced lifestyle can help mitigate mood-related side effects.
  3. Vision Issues (Specific to Andarine/S-4):
    Description: Andarine, a specific SARM, has been reported to cause vision issues, particularly a yellow tint or difficulty adjusting to low light conditions.
    Mitigation: Ceasing use typically resolves vision-related side effects. Users should consult with a healthcare professional if such issues arise.
  4. Liver Toxicity (Dependent on Compound and Dosage):
    Description: While SARMS are generally considered less hepatotoxic than traditional steroids, high doses or prolonged use may impact liver health.
    Mitigation: Staying within recommended dosage ranges and incorporating liver support supplements may help reduce the risk of liver-related side effects.
  5. Cardiovascular Health (Dependent on Compound and Dosage):
    Description: Some SARMS may have an impact on lipid levels and cardiovascular health, although the extent varies between compounds.
    Mitigation: Regular monitoring of lipid profiles and adopting a heart-healthy lifestyle can help mitigate cardiovascular risks.
  6. Estrogen Imbalance (Dependent on Compound):
    Description: Certain SARMS may cause an imbalance in estrogen levels, leading to issues like gynecomastia (enlarged breast tissue in males).
    Mitigation: Adjusting dosage and incorporating aromatase inhibitors may help manage estrogen-related side effects.

It’s crucial to note that individual responses to SARMS can vary, and not everyone will experience these side effects. Additionally, responsible use, adherence to recommended dosages, and consulting with a healthcare professional before and during use are essential practices to minimize risks associated with SARMS. As research on SARMS is ongoing, staying informed about the latest findings is advisable for anyone considering their incorporation into a fitness regimen.