Nicotinamide Mononucleotide vs Nicotinamide Riboside

In recent years, the pursuit of a healthier and longer life has led to the exploration of various supplements and compounds, many of which claim to boost cellular health and longevity. Two such compounds that have garnered significant attention are Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR). These molecules, both of which are precursors to nicotinamide adenine dinucleotide (NAD+), play a pivotal role in cellular energy production and are believed to have potential anti-aging properties. In this article, we will explore the distinctions between Nicotinamide Mononucleotide (NMN) vs Nicotinamide Riboside (NR), shedding light on their respective potential benefits.

Introduction of Nicotinamide Mononucleotide vs Nicotinamide Riboside

1. Nicotinamide Mononucleotide (NMN):

Nicotinamide Mononucleotide, commonly referred to as NMN, is a derivative of vitamin B3 (niacin) and is an essential component in the NAD+ synthesis pathway. NMN is found naturally in various foods like broccoli, cabbage, and avocados, albeit in small amounts. To harness its potential benefits, many individuals opt for NMN supplements.

2. Nicotinamide Riboside (NR):

Nicotinamide Riboside (NR) is another precursor to NAD+ and is also derived from vitamin B3. NR is present in trace amounts in foods like milk and can be obtained through dietary supplements.

3. Key Differences:

  1. Bioavailability: One of the primary distinctions between NMN and NR is their bioavailability. NR is thought to have better bioavailability, meaning it is more readily absorbed by the body compared to NMN. However, the research on this aspect is ongoing, and individual responses may vary.
  2. Dosage: The recommended dosage for NMN and NR supplements can differ. Users often take higher doses of NMN compared to NR. It is essential to consult with a healthcare professional before starting any supplementation regimen to determine the appropriate dosage for your specific needs.
  3. Conversion Efficiency: Both NMN and NR are precursors to NAD+, but the conversion process within the body varies. NR is converted directly into NAD+, whereas NMN must first be converted into NR before being transformed into NAD+. This has led some to argue that NR may be a more efficient choice.

4. Nicotinamide Mononucleotide Side Effects:

While NMN is generally considered safe when taken at recommended doses, some individuals may experience side effects, albeit rarely. It’s crucial to be aware of these potential side effects before incorporating NMN into your routine:
Digestive Issues: Some users have reported gastrointestinal discomfort, including nausea, diarrhea, or stomach cramps. To minimize these side effects, it is advisable to start with a lower dose and gradually increase it over time.
Allergic Reactions: In rare cases, individuals may develop allergic reactions to NMN supplements, such as hives, itching, or swelling. If you experience any allergic symptoms, discontinue use immediately and seek medical attention.
Interactions with Medications: NMN may interact with certain medications, so it’s essential to consult your healthcare provider if you are taking any prescription drugs to ensure there are no potential contraindications.


In the quest for a longer, healthier life, the choice between Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) may seem daunting. While both compounds show promise in supporting cellular health and longevity, the decision ultimately depends on individual preferences, needs, and responses.

As with any supplement, it is crucial to consult with a healthcare professional before incorporating NMN or NR into your daily regimen. Additionally, keep in mind that scientific research on these compounds is ongoing, and new insights may emerge over time.

Remember, there is no one-size-fits-all solution when it comes to supplements, and it’s essential to prioritize a balanced diet, exercise, and a healthy lifestyle alongside any supplementation regimen for optimal health and well-being.